Evaluation Profile Blood Glucose Cancer Patients with Type 2 Diabetes Mellitus complications after the use of glucocorticoids on Chemotherapy Regimen
ABSTRACT: Chemotherapy patients with a history of type 2 diabetes that undergo chemotheraphy and receive dexamethasone need special attention because dexamethason may increase blood glucose level. This study aims to determine the blood glucose level of cancer patients with type 2 diabetes mellitus after administration of glucocorticoids on chemotherapy regimens This study is a retrospective non experiment that conducted at Dr. Sardjito Hospital by evaluating the medical records of patients chemotherapy who have a history of type 2 diabetes than in January 2012 - December 2013. Blood glucose levels of patients before use and after use dexamethasone recorded and analyzed. A total of seventy-nine cases of type 2 diabetes patients who are undergoing chemotherapy and receive dexamethasone examined in this study. It is known that the average increase in blood glucose levels after the study subjects received 2 ampoules dexamethasone (10mg) was 133.38 (±65.77) mg/dL, whereas that received dexamethasone 4 ampoules (20mg) was 152.45 ( ±72.85) mg/dl. P value for elevation of blood glucose level between dexamethasone 2 ampoules (10mg) and 4 ampoules (20mg) are 0,001 and 0,000 respectively, it means that the elevations of blood glucose level is significant statistically. But the differences of elevation blood glucose level between dexamethasone 2 ampoules (10mg) and 4 ampoules (20mg) is only 19,08mg/dL and p = 0,377 that means that the differences is not significant. The conclusion of this research is there was an elevation of blood glucose level that significant statistically in cancer patients with type 2 diabetes whom use antidiabetics to control their blood glucose after receive dexamethasone on chemotherapy, but dose of glucocorticoids have no influence ststistically of this elevation of blood glucose level.
ABSTRACT: Chemotherapy patients with a history of type 2 diabetes that undergo chemotheraphy and receive dexamethasone need special attention because dexamethason may increase blood glucose level. This study aims to determine the blood glucose level of cancer patients with type 2 diabetes mellitus after administration of glucocorticoids on chemotherapy regimens This study is a retrospective non experiment that conducted at Dr. Sardjito Hospital by evaluating the medical records of patients chemotherapy who have a history of type 2 diabetes than in January 2012 - December 2013. Blood glucose levels of patients before use and after use dexamethasone recorded and analyzed. A total of seventy-nine cases of type 2 diabetes patients who are undergoing chemotherapy and receive dexamethasone examined in this study. It is known that the average increase in blood glucose levels after the study subjects received 2 ampoules dexamethasone (10mg) was 133.38 (±65.77) mg/dL, whereas that received dexamethasone 4 ampoules (20mg) was 152.45 ( ±72.85) mg/dl. P value for elevation of blood glucose level between dexamethasone 2 ampoules (10mg) and 4 ampoules (20mg) are 0,001 and 0,000 respectively, it means that the elevations of blood glucose level is significant statistically. But the differences of elevation blood glucose level between dexamethasone 2 ampoules (10mg) and 4 ampoules (20mg) is only 19,08mg/dL and p = 0,377 that means that the differences is not significant. The conclusion of this research is there was an elevation of blood glucose level that significant statistically in cancer patients with type 2 diabetes whom use antidiabetics to control their blood glucose after receive dexamethasone on chemotherapy, but dose of glucocorticoids have no influence ststistically of this elevation of blood glucose level.
