RISK FACTORS AFFECTING THE EVENTS IN THE PERIPHERAL INTRAVENOUS CHEMOTHERAPY extravasation Hospital Dr. Sardjito YEAR 2011-2013
ABSTRACT: Background: extravasation is a condition of drug or fluid leakage from vein into surrounding healthy tissue during chemotherapy regimens. Vesicants groups of chemotherapy drugs can cause tissue necrosis. The incidence of extravasation in chemotherapy regimens reported to be 1% to 7%. Risk factors assessed were the following types of drugs, cannula location, age, gender, hypertension, diabetes, number of medications, chemotherapy wards and frequency of chemotherapy as risk factors affecting extravasation event of peripheral intravenous chemotherapy. Extravasation is suspected when there is one or more signs and symptoms include the following patient complained of a burning, stinging, or pain at the puncture site, swollen, blistered at the puncture site, redness around the area of the stabbing, there is no blood flow back and change the quality of the drip . Objective: to determine the incidence of extravasation and risk factors that affect the extravasation of peripheral intravenous chemotherapy. Methods: The design of this study was nested case control study in which patients who received intravenous chemotherapy peripheral selected as cases and controls without extravasation then compared with existing risk factors. Results: event of chemotherapy extravasation as much as 12.7%. Multivariate analysis showed that the risk factors affecting the incidence of peripheral intravenous chemotherapy extravasation is the location of chemotherapy and chemotherapy wards. Power of risk factors on the incidence of chemotherapy extravasation from the smallest to the largest is the location of chemotherapy (p <0,000, OR = 2,365, 95% CI 1,55-3,63), and chemotherapy wards (p <0,000, OR = 3,948, CI 95% 2,12 -7,35). Conclusion: risk factors affecting event of peripheral intravenous chemotherapy extravasation are the location of chemotherapy and chemotherapy wards.
