EXPRESSION DIFFERENCES KI-67 AND PCNA IN TYPE serosum epithelial ovarian cancer, mucinous, endometrioid, CELL AND CLEAR
ABSTRACT: Background: Epithelial ovarian cancer is a type of ovarian cancer which has the highest incidence when compared with other types. Epithelial ovarian cancer has several subtypes with different pathogenesis pathways, but most ovarian carcinoma biomarker studies and current treatment protocols of this disease are still not subtype specific. Therefore specific biomarker that can complete the existing clinical parameters is needed, so that the diagnosis, prognosis, and management of each type can be more specific and optimal. Ki-67 and PCNA are markers of proliferation that have been widely studied in cancer incidence. Objective: To study the different expression of Ki-67 and PCNA in 4 types of epithelial ovarian cancer (serous, mucinous, endometrioid, and clear cell). Methods: Eighteen blocks paraffin of 4 types of epithelial ovarian cancer stained by immunohistochemistry with antibodies anti Ki-67 and PCNA. Expression of Ki-67 and PCNA are shown by the brown colour of tumor cell nuclei in 10 field of view randomly in every object glass. Differences in the expression of Ki-67 and PCNA in 4 types of epithelial ovarian cancer (serous, mucinous, endometrioid, and clear cell) are analyzed by Kruskal Wallis and Mann-Whitney. Results: The expression of Ki-67 and PCNA in 4 types of epithelial ovarian cancer by Kruskal Wallis test showed no significant results (p = 0.503 and p = 0.315). Mann- Whitney test on the samples also showed similar results (p> 0.05) Conclusions: There are no differences in the expression of Ki-67 and PCNA in 4 types of epithelial ovarian cancer (serous, mucinous, endometrioid, and clear cell). Keywords: epithelial ovarian cancer, Ki-67, PCNA
