DIFFERENCES IN THE PROPORTION OF EXPRESSION angiogenic vascular endothelial growth factor-A (VEGF-A) AND MICRO VESSEL DENSITY (MVD) NETWORK synchronous colorectal cancer METASTASIS AND METAKRONUS IN DR. Sardjito

DIFFERENCES IN THE PROPORTION OF EXPRESSION angiogenic vascular endothelial growth factor-A (VEGF-A) AND MICRO VESSEL DENSITY (MVD) NETWORK synchronous colorectal cancer METASTASIS AND METAKRONUS IN DR. Sardjito

ABSTRACT: Background. Colorectal cancer is a malignancy with a high incidence rate. Cancer growth and metastasis occurrence is highly dependent on angiogenesis process. Dependence on angiogenesis occurred since the size of the tumor is very small. Angiogenesis also reflect the potential for invasion and metastasis. Micro vessel density (MVD) with CD31 staining and VEGF-A is a marker of angiogenesis. Objective . Analyze differences in the proportion of expression VEGF-A and MVD in tissues synchronous and metachronous metastatic colorectal cancer Methods. A cross-sectional study design in patients with metastatic colorectal cancer tissue visiting Tulip clinic Dr. Sardjito Hospital, Yogyakarta from January 2007 to December 2014. The difference between the proportion of synchronous and metachronous metastatic colorectal cancer analyzed using Chi-Square, with a significance of p <0.05. Results. 63 tissue consists of 38 synchronous and 25 metachronous metastasis. 32 male patients (50.79%) and 31 women (49.21%), the average age is 53.97 Ã�± 10.9 years, the location of most cancers originate from the left intestine 55 (87.3%) compared to the right 6 (9.52%), with most metastases in the liver 32 (50.79%), adenocarcinoma dominates 57 (91,93%), with good differentiation 31 (52,54%). MVD median value of 24 (4-69) and VEGF-A 2.3 (0.4 to 12). Tissue with MVD> 24 (hypervascular) is 29 (46%) and less or equal 24 as many as 34 (54%) whereas high VEGF-A (> 2.3) and low (less or equal 2,3) equally 25 (50%). The proportion of hypervascular synchronous metastatic tissues significantly different than metachronous [22/38 (57.89%); 7/25 (28%); p = 0.02] whereas VEGF-A are no different [15/31 (48,38%); 10/19 (52,63%); p = 0.77]. Conclusions. Results showed that the proportion of hypervascular MVD in synchronous metastasis is higher than metachronous whereas VEGF-A are no different.