Expression of interleukin-6 NETWORK BASED ON DEGREE OF CANCER TUMOR DIFFERENTIATION Colorectal Adenocarcinoma
ABSTRACT: Background : Interleukin-6 (IL-6) had been shown to be a pleiotropic cytokine produced by tumor cell that act as growth factor. Colorectal cancer can produce IL-6, as a consequence there is a raising of IL-6 level in colon mucosa that shows excessive development of cell. Tumor differentiation grade had become one of prognostic factors in colorectal cancer but it is unclear whether the increase of IL-6 expression in colorectal cancer is related to tumor differentiation grade. Objectives :This reserach was held to find out the difference of tissue expression of IL-6 between well versus moderate and poor differentiation in colorectal adenocarcinoma. Methods : We performed a cross sectional study. The subject of this study was the resection preparation of colorectal tissue biopsies from all patients with adenocarcinoma colorectal with tissue samples that were sent to the department of Pathology Anatomy Dr. Sardjito between March 2010 and March 2014 who met the inclusion and exclusion criteria. Statistical analysis was done by Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Results : Fifty five samples of this study had been analysed. This study consisted of 31male subjects (56,3%) with mean age of 56,49 with standard deviation 12,56 years old. Twenty seven samples had well differentiation tumor grade (48,2%),20 samples had moderate differentiation (35,7%) and 8 samples had poor differentiation (14,3%). There was no significant difference interleukin-6 tissue expression between well versus moderate-poor differentiation (p=0,419). In subgroup analysis, there was also no significant difference of IL-6 tissue expression between well versus moderate versus poor differentiation group (p =0,596). Conclusion : There was no significant difference of tissue IL-6 expression between well versus moderate-poor differentiation group.
